Monday, July 14, 2014

Statin Drugs Will Harm Your Skin and Accelerate Aging

Statin Drugs Inhibit Enzymes Needed for Healthy Skin

The regulation of epidermal lipid synthesis by permeability barrier requirements.
Source Metabolism Section (111F), VA Medical Center, San Francisco, CA 94121.
A major function of the skin is to prevent the loss of fluids. The barrier to fluid loss resides in the intercellular lipids (primarily sterols, fatty acids, and sphingolipids) of the stratum corneum. The epidermis is a very active site of lipid synthesis and when the permeability barrier is disrupted by topical solvents or detergents a marked stimulation of sterol, fatty acid, and sphingolipid synthesis occurs. Essential fatty acid deficient mice, with a chronic disturbance in barrier function, also have an increase in epidermal lipid synthesis. When the defect in barrier function is artificially corrected by occlusion with a water vapor impermeable membrane the increase in epidermal lipid synthesis is prevented, suggesting that water flux may be a regulatory factor. The activity of the key rate limiting enzyme in cholesterol synthesis, HMG CoA reductase is increased following barrier disruption due to both an increased quantity of enzyme and an increase in activation state. Similarly, the activity of serine palmitoyl transferase, the rate limiting enzyme in sphingolipid synthesis is also increased following barrier disruption. Occlusion prevents the increase in HMG CoA reductase and serine palmitoyl transferase activity. When the increase in epidermal lipid synthesis is inhibited by occlusion the characteristic rapid return of stratum corneum lipids and recovery of barrier function is prevented. Moreover, when epidermal cholesterol synthesis is inhibited by lovastatin, an inhibitor of HMG CoA reductase, the rate of recovery of barrier structure and function is delayed. Similarly, B chloroalanine, an inhibitor of serine palmitoyl transferase and sphingolipid synthesis, also impairs barrier recovery. Thus, disruption of the barrier stimulates epidermal lipid synthesis which provides the lipids necessary for the repair of the barrier. The signals that initiate and coordinate this response are yet to be defined, but the understanding of this process may allow for pharmacological interventions that will specifically disrupt the barrier and allow for the transcutaneous delivery of drugs.

Note the bolded line. An example of how the statin drugs they want everyone to take will harm your skin and accelerate aging.  And your epidermis isn't the only tissue it does this to. Tissues inside and out.

Also, this study is about how the necessary lipids are stimulated after the your skin is harmed.  Which would of course be a part of healing. But is this an example of how are medical and pharmaceutical researchers think?  What we need is to damage ourselves in order stimulate healing? 

Wednesday, July 2, 2014

Homemade Coconut Milk

Make Homemade Coconut milk from Dried Coconut  

This recipe comes fom a vendor of coconut products that doesn't sell a canned coconut milk because they say there isn't a good one.  There's a video demonstration on their site here:

Homemade Coconut Milk Recipe

  • In a medium-size kettle, heat the water, but do not bring it to a boil.
  • Place the coconut in a blender and add 1 cup of the hot water.
  • Blend for 2-3 minutes.
  • Place a colander in a bowl and line the colander with 4 thicknesses of cheesecloth.
  • Pour the blended coconut mixture into the cheesecloth and twist to extract the milk, letting the milk go into the bowl.
  • Return the coconut pulp to the blender and add the remaining 1/2 cup of hot water.
  • Blend for 1-2 minutes, strain and press through the cheesecloth into the bowl.
Makes about 1 cup

Save  the leftover coconut pulp for pancakes & cookies!   

Mix the coconut with a couple mashed ripe bananas, a little salt and whatever else you'd like such as spices, a little cocoa powder, low sugar dark chocolate pieces, a spoonful of nut butter, etc.  Drop by spoonfuls onto cookie sheet & bake.  Also do with other things besides banana such as baked winter squash or sweet potatoes.  Mix with a little egg for pancakes or even better, with mashed sweet potato and egg.